Anti-Purkinje cell cytoplasmic and neuronal nuclear antibodies aid diagnosis of paraneoplastic autoimmune neurological disorders.

Diagnosis and treatment of paraneoplastic neurological disorders.

In about two thirds of cases, patients with paraneoplastic neurological disorders present to the neurologist without a known tumor. Due to the ongoing immune response, this tumor tends to stay biologically relatively benign, and therefore difficult to diagnose. In patients with a known tumor, the neurological symptoms often precede a tumor recurrence. In both scenarios, anti-neuronal antibodies...

Anti-amphiphysin I antibodies in patients with paraneoplastic neurological disorders associated with small cell lung carcinoma.

Patients with stiff man syndrome and breast cancer develop anti-amphiphysin I antibodies that primarily recognise the C terminus of the protein. Anti-amphiphysin I antibodies have also been identified in a few patients with paraneoplastic neurological disorders (PND) and small cell lung cancer (SCLC). The frequency of anti-amphiphysin I antibodies in patients with SCLC and PND was analysed and ...

Association of Paraneoplastic Neurological Disorders With Glutamic Acid Decarboxylase Antibodies.

Immunopathogenesis of paraneoplastic neurological syndromes associated with anti-Hu antibodies

Paraneoplastic neurological disorders (PNDs) are syndromes that develop in cancer patients when an efficient antitumor immune response, directed against antigens expressed by both malignant cells and healthy neurons, damages the nervous system. Herein, we analyze existing data on the mechanisms of loss of self tolerance and nervous tissue damage that underpin one of the most frequent PNDs, the ...

Paraneoplastic neurological disorders

M. COJOCARU, MD, PhDa; Inimioara Mihaela COJOCARU, MD, PhDb; Isabela SILOSI, MD, PhDc aPhysiology Department, Faculty of Medicine, ”Titu Maiorescu” University, Bucharest, Romania bNeurology Clinic, “Carol Davila” University of Medicine and Pharmacy, “Colentina” Clinical Hospital, Bucharest, Romania cImmunology Department, Faculty of Medicine and Pharmacy, Craiova, Romania EDITORIALS Mædica a Jo...